ABSTRACT
DRESS syndrome (drug reaction with eosinophilia and systemic symptoms), previously named "drug hypersensitivity syndrome", is a severe adverse drug reaction characterized by skin rash, fever, lymph node enlargement and internal organ involvement. We report on a 7-year old girl who developed DRESS syndrome caused by penicillin V treatment.
El síndrome DRESS (así llamado por las indíciales del inglés "drug reaction with eosinophilia y systemic symptoms ") es una reacción a medicamentos, acompañada por eosinofilia y síntomas sistémicos. Conocida anteriormente como "síndrome de hipersensibilidad a los medicamentos, se trata de una reacción adversa severa a los medicamentos, caracterizada por erupción cutánea, fiebre, agrandamiento de los ganglios y compromiso de órganos internos. El presente trabajo reporta el caso de una niña de 7 años de edad, que desarrolló el síndrome DRESS a partir de un tratamiento con penicilina V.
Subject(s)
Child , Female , Humans , Anti-Bacterial Agents/adverse effects , Drug Eruptions/etiology , Eosinophilia/chemically induced , Fever/chemically induced , Lymphatic Diseases/chemically induced , Penicillin V/adverse effects , Diagnosis, Differential , Drug Eruptions/diagnosis , Drug Hypersensitivity , Eosinophilia/diagnosis , Fever/diagnosis , Lymphatic Diseases/diagnosis , Pharyngitis/drug therapy , Syndrome , Tonsillitis/drug therapySubject(s)
Adolescent , Anticonvulsants/adverse effects , Carbamazepine/adverse effects , Conjunctivitis, Allergic/chemically induced , Drug Eruptions/etiology , Drug Hypersensitivity/etiology , Dyspnea/chemically induced , Exanthema/chemically induced , Female , Fever/chemically induced , Humans , Lymphatic Diseases/chemically induced , SyndromeABSTRACT
Trichloroethylene, a chlorinated hydrocarbon has been reported to cause many adverse health effects. This paper describes a female patient presenting with rather unusual manifestation secondary to trichloroethylene (TCE) exposure, i.e. hepatitis and generalized dermatitis. The diagnosis was confirmed by positive skin patch testing with 50 per cent TCE solution. After withdrawal from the exposure site, her symptoms improved and liver function test returned to baseline level after a three-months period of follow-up. TCE induced immunologic reaction has been postulated as the pathological process of this illness.
Subject(s)
Adolescent , Dermatitis, Occupational/etiology , Female , Fever/chemically induced , Chemical and Drug Induced Liver Injury/etiology , Humans , Lymphatic Diseases/chemically induced , Occupational Diseases/chemically induced , Solvents/adverse effects , Trichloroethylene/adverse effectsABSTRACT
The authors report 3 cases of temporary generalized lymphoadenopathy directly related to Lamprene (Clofazimine) consumption. It appears that this side effect has never been reported in the literature.